Journal of Medicinal Food 6, 157-61

Hora, J.J., Maydew, E.R., Lansky, E.P., Dwivedi, C., 2003. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. Journal of Medicinal Food 6, 157-61.

Pomegranate seed oil was investigated for possible skin cancer chemopreventivePomegranate Abstracts efficacy in mice. In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD(1) mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly promotion using 12-O-tetradecanoylphorbol 13-acetate (TPA). The experimental group was pretreated with 5% pomegranate seed oil prior to each TPA application. Tumor incidence, the number of mice containing at least one tumor, was 100% and 93%, and multiplicity, the average number of tumors per mouse, was 20.8 and 16.3 per mouse after 20 weeks of promotion in the control and pomegranate seed oil-treated groups, respectively (P