Journal of Medicinal Food 7, 274-83

Albrecht, M., Jiang, W.,, Kumi-Diaka, J., Lansky, E.P., Gommersall, L.M., Patel, A., Mansel, R.E., Neeman, I., Geldof, A.A., Campbell, M.J. , 2004. Pomegranate extracts potently suppress proliferation, xenograft growth, and Pomegranate Abstractsinvasion of human prostate cancer cells. Journal of Medicinal Food 7, 274-83.

We completed a multicenter study of the effects of pomegranate cold-pressed (Oil) or supercritical CO(2)-extracted (S) seed oil, fermented juice polyphenols (W), and pericarp polyphenols (P) on human prostate cancer cell xenograft growth in vivo, and/or proliferation, cell cycle distribution, apoptosis, gene expression, and invasion across Matrigel, in vitro. Oil, W, and P each acutely inhibited in vitro proliferation of LNCaP, PC-3, and DU 145 human cancer cell lines. The dose of P required to inhibit cell proliferation of the prostate cancer cell line LNCaP by 50% (ED(50)) was 70 microg/mL, whereas normal prostate epithelial cells (hPrEC) were significantly less affected (ED(50) = 250 g/mL). These effects were mediated by changes in both cell cycle distribution and induction of apoptosis. For example, the androgen-independent cell line DU 145 showed a significant increase from 11% to 22% in G(2)/M cells (P

PMID: 15383219 [PubMed – indexed for MEDLINE